English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Conversion of CD4 + CD25 + FOXP3 + T regulatory cells (T regs ) from the immature (CD45RA + ) to mature (CD45RO + ) phenotype has been shown during development and allergic reactions. The relative frequencies of these T reg phenotypes and their responses to oxidative stress during development and allergic inflammation were analysed in samples from paediatric and adult subjects. The FOXP3 low CD45RA + population was dominant in early childhood, while the percentage of FOXP3 high CD45RO + cells began increasing in the first year of life. These phenotypic changes were observed in subjects with and without asthma. Further, there was a significant increase in phosphorylated ERK1/2 (pERK1/2) protein in hydrogen peroxide (H 2 O 2 )-treated CD4 + CD25 high cells in adults with asthma compared with those without asthma. Increased pERK1/2 levels corresponded with increased Ca 2+ response to T cell receptor stimulation. mRNA expression of peroxiredoxins declined in T regs from adults with asthma. Finally, CD4 + CD25 high cells from paediatric subjects were more sensitive to oxidative stress than those from adults in vitro. The differential T reg sensitivity to oxidative stress observed in children and adults was likely dependent on phenotypic CD45 isoform switching. Increased sensitivity of T reg cells from adults with asthma to H 2 O 2 resulted from a reduction of peroxiredoxin-2, -3, -4 and increased pERK1/2 via impaired Ca 2+ response in these cells.

Surface Phenotype Changes and Increased Response to Oxidative Stress in CD4+CD25high T Cells