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Potential alternative therapeutic strategies for immune-mediated disorders are being increasingly recognized and are studied extensively. We previously reported the therapeutic potential of Brugia malayi derived recombinant cystatin (r Bma Cys) in attenuating clinical symptoms of experimental colitis. The aim of this study was to elucidate the mechanisms involved in the r Bma Cys-induced suppression of inflammation in the colon. Our results show that, the frequency of CD4 + CD25 + FoxP3 + regulatory T-cells was elevated in the colon and mesenteric lymph nodes. Similarly, the peritoneal macrophages recovered from the r Bma Cys-treated colitis mice were alternatively activated and displayed reduced expression of TNF-α and IL-6. Another finding was significant increases in IgM + B1a-cells in the peritoneal cavity of mice following r Bma Cys-treatment. These findings suggested that the regulatory cell network promoted by the r Bma Cys in the colon and associated lymphoid tissues is important for its anti-inflammatory activity in the dextran sulfate sodium (DSS)-induced colitis mice.

biomedicines

Cystatin from Filarial Parasites Suppress the Clinical Symptoms and Pathology of Experimentally Induced Colitis in Mice by Inducing T-Regulatory Cells, B1-Cells, and Alternatively Activated Macrophages