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The present study evaluated the  IL8 -251 A/T polymorphism in samples from 74 patients with chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy donors (CG). The correlations of this polymorphism with plasma IL-8 and disease stage were calculated. Polymorphisms were identified by real-time PCR. IL-8 was measured by enzyme-linked immunosorbent assay. The  IL8 -251 A/T genotype was not associated with susceptibility to infection by HBV or HCV. The wild-type allele (A) was associated with higher levels of inflammation ( p  = 0.0464) and fibrosis scores ( p  = 0.0016) in the HBV group, representing an increased risk for increased inflammatory activity ( OR  = 1.84;  p  = 0.0464) and for high fibrosis scores ( OR  = 2.63;  p  = 0.0016). Viral load was higher in HBV patients with polymorphic genotypes (TA and TT) at the  IL8 -251 A/T polymorphism than in those with the wild-type genotype ( p  = 0.0272 and  p  = 0.0464, respectively). Plasma IL-8 was higher among patients infected with HBV or HCV than in the control group ( p  = 0.0445 and  p  = 0.0001, respectively). The polymorphic genotype was associated with lower IL-8 than the wild-type genotype in the HBV group ( p  = 0.0239) and the HCV group ( p  = 0.0372). The wild-type genotype for  IL8 -251 A/T and high IL-8 were associated with a worse prognosis for infections; therefore, they may contribute to viral persistence and the development of more severe forms of chronic viral liver diseases.

The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection