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Short-lived turquoise killifish ( Nothobranchius furzeri ) have become a popular model organism for neuroscience. In the present paper we study for the first time their behavior in the novel tank diving test and the levels of mRNA of various 5-HT-related genes in brains of 2-, 4- and 6-month-old males and females of N. furzeri . The marked effect of age on body mass, locomotor activity and the mRNA level of Tph1b , Tph2 , Slc6a4b , Mao , Htr1aa , Htr2a , Htr3a , Htr3b , Htr4 , Htr6 genes in the brains of N. furzeri males was shown. Locomotor activity and expression of the Mao gene increased, while expression of Tph1b , Tph2 , Slc6a4b , Htr1aa , Htr2a , Htr3a , Htr3b , Htr4 , Htr6 genes decreased in 6-month-old killifish. Significant effects of sex on body mass as well as on mRNA level of Tph1a , Tph1b , Tph2 , Slc6a4b , Htr1aa , 5-HT2a , Htr3a , Htr3b , Htr4 , and Htr6 genes were revealed: in general both the body mass and the expression of these genes were higher in males. N. furzeri is a suitable model with which to study the fundamental problems of age-related alterations in various mRNA levels related with the brains 5-HT system.

biomolecules

Age-Related Alterations in the Behavior and Serotonin-Related Gene mRNA Levels in the Brain of Males and Females of Short-Lived Turquoise Killifish (Nothobranchius furzeri)