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Extensive in vivo replacement of hydrogen by deuterium, a stable isotope of hydrogen, induces a distinct stress response, reduces cell growth and impairs cell division in various organisms. Microalgae, including Chlamydomonas reinhardtii , a well-established model organism in cell cycle studies, are no exception. Chlamydomonas reinhardtii , a green unicellular alga of the Chlorophyceae class, divides by multiple fission, grows autotrophically and can be synchronized by alternating light/dark regimes; this makes it a model of first choice to discriminate the effect of deuterium on growth and/or division. Here, we investigate the effects of high doses of deuterium on cell cycle progression in C. reinhardtii . Synchronous cultures of C. reinhardtii were cultivated in growth medium containing 70 or 90% D 2 O. We characterize specific deuterium-induced shifts in attainment of commitment points during growth and/or division of C. reinhardtii , contradicting the role of the "sizer" in regulating the cell cycle. Consequently, impaired cell cycle progression in deuterated cultures causes (over)accumulation of starch and lipids, suggesting a promising potential for microalgae to produce deuterated organic compounds.

To Divide or Not to Divide? How Deuterium Affects Growth and Division of Chlamydomonas reinhardtii