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Essential oils obtained by hydrodistillation of  Montanoa quadrangularis  leaves, flowers, and stems were analyzed by GC and GC/MS techniques revealing myrcene, limonene, β-phellandrene, and sabinene among the main components. The aim of the present study was to evaluate the MDR modulator activity on human MDR1 gene transfected mouse lymphoma cell line and the antimicrobial activity on the essential oils obtained from different parts of the species under investigation. The results revealed that MQL caused a similar increase in the fluorescence activity of the cells at 0.02 μL/mL comparing to the Verapamil ®  value. The antimicrobial assay was carried out according to the disc diffusion method. Five different bacterial strains ( Staphylococcus epidermidis ,  Bacillus subtilis ,  Pseudomonas aeruginosa ,  Escherichia coli  AG 100, and  Escherichia coli  AG100 A ) were treated with the essential oils and the zones of inhibition were determined on TSA plates and TSA agar plates supplemented with Tween 20. MQF and MQL showed activity against  B. subtilis ,  S. epidermidis , and  E. coli  AG 100 A  while MQS was only active against  E. coli  AG 100 A  on TSA agar plates experiment. In case of TSA agar plates supplemented with 0.1  v / v % Tween 20 detergent, MQF showed inhibition on  B. subtilis ,  S. epidermidis , and  E. coli  AG 100 A ; MQL was active against  B. subtilis ,  E. coli  AG 100,  and E. coli  AG 100 A  while MQS was only active against  E. coli  AG 100 A .

biomolecules

Antibacterial Activity and Reversal of Multidrug Resistance of Tumor Cells by Essential Oils from Fresh Leaves, Flowers, and Stems of Montanoa quadrangularis Schultz Bipontinus (Asteraceae) Collected in Mérida—Venezuela