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In this paper, an on-line control strategy that aims to guarantee the maintenance of a minimum dissolved oxygen (DO) concentration during aerobic fed-batch fermentations is proposed. It is a difficult task to maintain the DO concentration, especially during fed-batch fermentation, due to strongly nonlinear, variable conditions and probe dynamics. The algorithm uses information contained in the slope of the profile of the DO, as this evolves in a timely way to adapt to process variations. Moving window technology was used to track the DO tendency variation. This method was tested in Corynebacterium glutamicum and Pichia pastoris fermentations. The performance of tendency control was compared with that of manual control. The experimental results clearly show that the on-line tendency control of DO is effective and can also reduce the frequency of activity of the controller as well as the manpower burden.

On-Line Tendency Control of Dissolved Oxygen Concentration during Aerobic Fed-Batch Fermentations