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Dietary lipids provide energy for growth and development and provide fatty acids necessary for normal structure and biological function. However, oxidized lipids cause oxidative stress and intestinal damage. An 8-week feeding trial with fresh fish oil (FFO, control group), oxidized fish oil (OFO), and taurine-supplemented diets (OFOT, OFO + 0.2% of taurine) was conducted to evaluate the protective effect of taurine on oxidized fish-oil-induced liver oxidative stress and intestine impairment in juvenile  I  ctalurus   pun  cta  tus . The results showed that (1) Growth performance was significantly lower in fish fed OFO than in those fed other diets, whereas the opposite occurred in the hepatosomatic index. (2) OFO-feeding significantly increased lipid deposition compared with the FFO group. The addition of taurine ameliorated the OFO-induced increase in lipid vacuolization in the liver, significantly upregulated  lpl  mRNA expression, and downregulated  fas  and  srebp1  mRNA expression. (3) OFO-feeding significantly reduced oxidative damage of liver. Compared with the OFO group, the OFOT group remarkably upregulated antioxidant enzyme mRNA expression through the Nrf2-Keap1 signaling pathway based on the transcriptional expression. (4) OFO diets induced intestinal physical and immune barrier damage. Compared with the OFO group, OFOT diets remarkably downregulated  il-1β ,  il-6 ,  tnf-α , and  il-8  mRNA expression and upregulated  tgf-β  mRNA expression through the NF-κB signaling pathway. Besides, the addition of taurine to OFO diets significantly upregulated  zo-2  and  zo-1  mRNA expression, and downregulated  claudin-15  and  claudin-12  mRNA expression. In conclusion, oxidized-fish-oil diets can cause negative physiological health effects in  I  ctalurus   pun  cta  tus , while adding taurine can increase growth and antioxidant ability, reduce lipid deposition, and improve intestinal health.

antioxidants

The Protective Effect of Taurine on Oxidized Fish-Oil-Induced Liver Oxidative Stress and Intestinal Barrier-Function Impairment in Juvenile Ictalurus punctatus