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Oxidative stress and antioxidants play an important role in obesity etiopathology. Genetic variants, including single nucleotide polymorphisms (SNPs) of the antioxidant-related genes, may impact disease risk in several populations. This preliminary study aimed to explore the association of 12 SNPs related to superoxide dismutase ( SOD ), catalase ( CAT ), glutathione peroxidase ( GPX ), glutathione-S-transferase ( GST ), and nitric oxide synthase ( NOS ) genes with obesity susceptibility in a Saudi population. A total of 384 unrelated participants, including 154 (40.1%) obese individuals, were enrolled. TaqMan OpenArray Genotyping assays were used. Six SNPs were significantly more prevalent in obese cohorts: (1)  GSTM1  rs1056806*C/T; (2)  SOD1  rs2234694*A; (3)  SOD2  rs4880*G; (4)  SOD3  rs2536512*A; (5)  GPX1  rs1800668*A; (6)  NOS3  rs1799983*G. Four SNPs were associated with higher obesity risk under heterozygote and dominant models for  GSTM1  rs1056806 (C/T), homozygote model for  SOD2  rs4880 (A/G), and homozygote and recessive models for  GPX1  rs1800668 (A/G). In contrast,  SOD3  rs2536512 (A/G) were less likely to be obese under heterozygote and dominant models. The CGAG, CAAA, TGGG, and CGAG combined genotypes showed a higher risk of obesity. In conclusion, the present results suggest that oxidative-stress-related genetic determinants could significantly associate with obesity risk in the study population.

antioxidants

Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) Gene Variants Analysis in an Obese Population: A Preliminary Case-Control Study