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Previous studies demonstrated that polymorphisms in the μ-calpain ( CAPN1 ) and calpastatin ( CAST ) genes had significant effects on meat tenderness in different cattle populations. The aim of this study was to validate the potential association of seven single nucleotide polymorphisms (SNPs) harbored in these two candidate genes with meat tenderness in the Longissimus thoracis (LT) and Semimembranosus (SM) muscles. A total of 1000 animals were genotyped using TaqMan SNP genotyping arrays, and the meat tenderness of two muscle (LT and SM at 7 days post-slaughter) was assessed based on Warner-Bratzler WBSF (WBSF) testing. We observed significant associations of the CAPN1 :c.580T&gt;C, CAPN1 :c.658T&gt;C and CAST :c.1985G&gt;C polymorphisms ( p &lt; 0.05) with the WBSF values in the LT and SM muscles. Additive effects of the C allele in CAPN1 :c.580T&gt;C and CAST :c.1985G&gt;C were associated with an increase of 0.16 and 0.15 kg, and 0.08 and 0.26 kg WBSF in the LT and SM, respectively; CAPN1 :c.658T&gt;C had negative effects on the WBSFs. Furthermore, six reconstructed haplotypes demonstrated significant associations with WBSF values ( p &lt; 0.05). In conclusion, the significant associations identified between the SNPs in CAPN1 , CAST and WBSF values could be utilized in marker-assisted selection programs in order to improve the beef tenderness of Hanwoo cattle.

Validation Study of SNPs in CAPN1-CAST Genes on the Tenderness of Muscles (Longissimus thoracis and Semimembranosus) in Hanwoo (Korean Cattle)