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Organic manganese (Mn) sources can replace inorganic Mn as dietary Mn supplements in poultry. To compare the uptake of Mn from the Mn-lysine complex (MnLys) and MnSO 4 , we first established the primary chicken intestinal epithelial cells (IECs) model and used it to determine Mn uptake. The MnLys increased the uptake of Mn compared to MnSO 4 . The uptake of Mn decreased in the IECs with Fe addition in the medium regardless of the Mn sources. The MnLys decreased the Mn 2+ efflux transporter ferroportin 1 (FPN1) mRNA level but did not influence the Mn 2+ influx transporter divalent metal transporter 1 (DMT1) mRNA expression when compared to MnSO 4 . The results above indicated that the increase of Mn accumulation for MnLys at least partly was due to the decrease of Mn efflux by reduced FPN1 expression. The addition of N -ethylmaleimide, an L-lysine transport system y + inhibitor, decreased the uptake of Mn from MnLys but did not affect the uptake of Mn from MnSO 4 . The cycloheximide, as an L-lysine transport system b 0,+ activator, increased the uptake of Mn from MnLys, whereas they did not influence the uptake of Mn from MnSO 4 . The MnLys increased the system y + members cationic amino acid transporter (CAT) 1 and CAT2, and system b 0,+ components rBAT and b 0,+ AT mRNA expression when compared to MnSO 4 . These results suggested that the uptake of MnLys complex might be transported by CAT1/2 and system b 0,+ , which was different from the ionized Mn 2+ uptake pathway. In conclusion, the uptake of Mn from MnLys complex not only might be uptake through the ionized Mn 2+ pathway, but also appeared to be transported through the CAT1/2 and system b 0,+ in primary chicken IECs.

Uptake of Manganese from the Manganese-Lysine Complex in Primary Chicken Intestinal Epithelial Cells