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Simple Summary   Astragalus membranaceus  is a widely used traditional Chinese herb that has been used by humans for hundreds of years. The Qinghai-Tibetan plateau (QTP) is regarded as one of the remaining ‘Green’ places in the world. With the fast-developing intensive livestock production, sustainable and environmentally-friendly practices are required urgently on the QTP. In the current study, Tibetan sheep were supplemented with the root of  Astragalus membranaceus  (AMT) to reduce the use of chemical veterinary drugs and antibiotics, and to examine the effect on rumen bacteria, the antioxidant capacities and immunity indices of small intestinal mucosa and meat tissue, and the liver metabolome responses.    Abstract  Natural, non-toxic feed additives can potentially replace chemical medications and antibiotics that are offered sheep to improve performance. In the present study, Tibetan sheep were supplemented with the root of  Astragalus membranaceus  (AMT), a traditional herb used widely in China. Twenty-four male Tibetan sheep (31 ± 1.4 kg; 9-month-old) were assigned randomly to one of four levels of supplementary AMT: 0 g/kg (A 0 ), 20 g/kg (A 20 ), 50 g/kg (A 50 ) and 80 g/kg (A 80 ) dry matter intake (DMI). The A 50  and A 80  groups increased the diversity of rumen bacteria on d 14 and the relative abundances of fiber decomposing bacteria. Supplementary AMT upregulated the metabolism of vitamins, nucleotides, amino acids and glycan, and downregulated the metabolism of lipids and carbohydrates. In addition, supplementary AMT enriched rumen bacteria for drug resistance, and reduced bacteria incurring cell motility. In general, AMT supplementation increased the concentrations of catalase (CAT), superoxide dismutase (SOD) total antioxidant capacity (T-AOC) and secretory immunoglobulin A (sIgA) in the small intestinal mucosa and CAT and SOD in meat tissue. The liver tissue metabolome response showed that AMT in the A 80  lambs compared to the A 0  lambs upregulated the metabolites for energy synthesis. It was concluded that supplementary  A. membranaceus  increased the relative abundances of fiber decomposing bacteria and improved the antioxidant capacities and immunity indices of small intestinal mucosa and meat tissue in Tibetan sheep.

animals

Astragalus membranaceus Alters Rumen Bacteria to Enhance Fiber Digestion, Improves Antioxidant Capacity and Immunity Indices of Small Intestinal Mucosa, and Enhances Liver Metabolites for Energy Synthesis in Tibetan Sheep