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Simple Summary  Aflatoxin B 1  (AFB 1 ) is a common and devastating food-borne fungal toxic in the broiler industry. AFB 1  has adverse effects on the world poultry industry as it impairs the health, performance, intestinal integrity, and immunity of broilers. There has been a great economic concern in the global poultry production, leading to billions of dollars loss every year due to AFB 1 . Antibiotic-free broiler production relies on feed supplementation as an alternative to antibiotic usage. We previously reported that dietary supplementation with lycopene (LYC) has shown a promising effect on performance and intestinal integrity in the broilers infected with AFB 1 . However, there are few reports on the effects of LYC on the intestinal development and antioxidant capacity in the broiler against AFB 1 . The present study was conducted to evaluate the effects of LYC supplementation on the intestinal immune function, barrier function, and antioxidant capacity of broilers fed with an AFB 1  contaminated diet. The findings of this research highlighted that the diet supplemented with LYC has a potential effect to improve intestinal health and reduce AFB 1  related oxidative and inflammatory status. Hence, this study suggested that addition of LYC in broiler poultry production alleviates the AFB 1  toxicity.    Abstract  The present study aims to evaluate the effects of lycopene (LYC) supplementation on the intestinal immune function, barrier function, and antioxidant capacity of broilers fed with aflatoxinB1 (AFB 1 ) contaminated diet. A total of 144 one-day-old male Arbor Acres broilers were randomly divided into three dietary treatment groups; each group consisted of six replicates (eight birds in each cage). Treatments were: (1) a basal diet containing neither AFB 1  nor LYC (Control), (2) basal diet containing 100 µg/kg AFB 1 , and (3) basal diets with 100 µg/kg AFB 1  and 200 mg/kg LYC (AFB 1  and LYC). The results showed that dietary LYC supplementation ameliorated the AFB 1  induced broiler intestinal changes by decreasing the inflammatory cytokines interferon-γ (IFN-γ), interleukin 1beta (IL-1β), and increasing mRNA abundances of cludin-1 (CLDN-1) and zonula occludens-1 (ZO-1) in the jejunum mucosa. On the other hand, AFB 1 -induced increases in serum diamine oxidase (DAO) activities, D-lactate concentration, mucosal malondialdehyde (MDA), and hydrogen peroxide (H 2 O 2 ) concentrations were reversed by dietary LYC supplementation ( p  < 0.05). Additionally, LYC supplementation ameliorated the redox balance through increasing the antioxidant enzyme activities and their related mRNA expression abundances compared to AFB 1  exposed broilers. In conclusion, dietary supplementation with LYC could alleviate AFB 1  induced broiler intestinal immune function and barrier function damage and improve antioxidants status.

animals

Dietary Lycopene Supplementation Could Alleviate Aflatoxin B1 Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers