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We evaluated the dietary effects of multiple probiotics in Jeju native pigs, using basal diet and multi-probiotic Lactobacillus (basal diet with 1% multi-probiotics) treatments ( n = 9 each) for 3 months. We analyzed growth performance, feed efficiency, backfat thickness, blood parameters, hematological profiles, adipokines, and immune-related cytokines in pig tissues. Average daily gain, feed intake, feed efficiency, backfat thickness, and body weight were not significantly different between both groups. In Lactobacillus group, total protein ( p &lt; 0.08) and bilirubin ( p &lt; 0.03) concentrations increased; blood urea nitrogen ( p &lt; 0.08), alkaline phosphatase ( p &lt; 0.08), and gamma-glutamyltransferase ( p &lt; 0.08) activities decreased. Lactobacillus group showed decreased adiponectin ( p &lt; 0.05), chemerin ( p &lt; 0.05), and visfatin expression in adipose tissues, and increased TLR4 ( p &lt; 0.05), MYD88 ( p &lt; 0.05), TNF-α ( p &lt; 0.001), and IFN-γ ( p &lt; 0.001) expression in the liver. Additionally, NOD1 ( p &lt; 0.05), NOD2 ( p &lt; 0.01), and MYD88 ( p &lt; 0.05) mRNA levels in proximal colon tissue upregulated significantly. Colon, longissimus dorsi muscle, fat tissue, and liver histological analyses revealed no significant differences between the groups. Conclusively, Lactobacillus supplementation improved liver function and reduced cholesterol levels. Its application may treat metabolic liver disorders, especially cholesterol-related disorders.

Multi-Probiotic Lactobacillus Supplementation Improves Liver Function and Reduces Cholesterol Levels in Jeju Native Pigs