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Simple Summary  Hyaluronic acid injections into the stifle are often used for managing osteoarthritis in dogs. Giving hyaluronic acid orally would be easier, but to date we do not have enough information regarding its effects when administered by this route. For this reason, in this study we evaluated the effects of oral administration of hyaluronic acid in dogs with cranial cruciate ligament rupture after surgical resolution. Dogs were divided into two groups that received either oral hyaluronic acid or a placebo. We measured changes in several biomarkers of osteoarthritis before surgery, and at ten weeks after surgery. Results showed significant improvements in some of these biomarkers, namely synovial fluid levels of hyaluronic acid and paraoxonase-1. These changes indicate that post-op oral administration of hyaluronic acid may be effective for the management of stifle osteoarthritis in the dog.    Abstract  Hyaluronic acid (HA) intraarticular injection is used in the management of osteoarthritis in veterinary medicine. However, HA oral administration is less common given the scarce currently available scientific evidence. This study was aimed at evaluating the effects of oral HA administration on synovial fluid concentrations of several selected biomarkers in dogs with cranial cruciate ligament (CCL) injury operated on using the tibial tuberosity advancement (TTA) technique. Fifty-five dogs were included in this prospective, randomized, double-blind, clinical study; they were randomly assigned to receive either a placebo (group A; n = 25) or HA (group B; n = 30) orally for 10 weeks. Synovial fluid samples were obtained before surgery, and at 10 weeks postoperatively to measure concentrations of HA, haptoglobin, nitric oxide, and paraoxonase-1. After 10 weeks, group HA showed a significant increase in HA concentration ( p  = 0.0016) and a significant decrease in PON-1 concentration ( p  = 0.011) compared to baseline. In conclusion, post-op oral HA administration in canine patients with CCL injury leads to improvements in osteoarthritis biomarkers, namely higher synovial fluid HA concentrations and reduced synovial fluid paraoxonase-1 concentrations. These findings support the bioavailability of orally-administered HA and its usefulness in improving biomarkers of osteoarthritis.

Effects of Oral Hyaluronic Acid Administration in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury