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Simple Summary  The mRNA expression of Interferon-τ ( IFNT ), IFN stimulated genes ( ISG15 ,  CTSL1 ,  RSAD2 ,  SLC2A1 ,  CXCL10 , and  SLC27A6 ), Peroxisome proliferator-activated receptors ( PPARA ,  D , and  G ), and Retinoid X receptors ( RXRA ,  B , and  G ) genes and proteins (IFNT, ISG15, CXCL10, PPARG, RXRG, SLC2A1, and SLC27A6) were lower and MUC1 at mRNA and protein levels, was greater in gestation day (GD) 16 embryo and corresponding endometrium of subclinical endometritis cows, and in cows following transfer of poor quality embryo (Grade 3). All genes and proteins but MUC1 expression was lower in GD16 tubular conceptus and corresponding endometrium vs. GD16 filamentous conceptus and matching endometrium in cows with SCE and in cows following the transfer of Grade 3 embryo. Disrupted embryo-uterine communication by altered expression of candidate genes in SCE cows, and in cows following the transfer of poor GD7 embryo negatively programs the conceptus development and plausibly affects the conceptus survival.Abstract  Effect of the gestational day (GD) 7 embryo quality grade (QG) and subclinical endometritis (SCE) on mRNA and protein expressions of candidate genes [Interferon-τ ( IFNT ), IFN stimulated genes ( ISG15, CTSL1, RSAD2, SLC2A1, CXCL10, and SLC27A6 ), Peroxisome proliferator activated receptors ( PPARA, D, and G ), Retinoid X receptors ( RXRA, B,  and  G ), and Mucin-1 ( MUC1 )] in GD16 conceptus and corresponding endometrium were evaluated. After screening of performance records ( n  = 2389) and selection of repeat breeders ( n  = 681), cows with SCE (≥6% polymorphonuclear neutrophils—PMN;  n  = 180) and no-SCE (<6%PMN;  n  = 180) received GD7 embryos of different QGs. Based on GD16 conceptus recovery, cows with SCE ( n  = 30) and No- SCE ( n  = 30) that received GD7 embryos QG1 (good,  n  = 20), 2 (fair,  n  = 20), and 3 (poor,  n  = 20) were included for gene analysis. mRNA and protein expressions (IFNT, ISG15, CXCL10, PPARG, RXRG, SLC2A1, and SLC27A6) differed between SCE and embryo QG groups. All genes but  MUC1  and all proteins but MUC1 expression was greater in filamentous conceptus and corresponding endometrium vs. tubular conceptus and matching endometrium in SCE and embryo QG groups. In conclusion, disrupted embryo-uterine communication by altered expression of candidate genes in SCE cows, and in cows following the transfer of poor embryo negatively programs the conceptus development and plausibly affects conceptus survival.

animals

mRNA Expressions of Candidate Genes in Gestational Day 16 Conceptus and Corresponding Endometrium in Repeat Breeder Dairy Cows with Suboptimal Uterine Environment Following Transfer of Different Quality Day 7 Embryos