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Simple Summary  As antibiotic resistance increases globally, alternatives to antibiotics are increasingly being investigated as growth promoters, as well as preventive and therapeutic agents, particularly in agriculture. Equally important is the need for investigation into the effects of antibiotic alternatives on antibiotic resistance and particularly their risk for co-selection. In this study, we explored the prevalence of antibiotic-resistant  Escherichia coli  and  Enterococcus  spp. in cattle fed zinc, menthol or a combination of the two. We found that zinc supplementation was associated with higher levels of macrolide resistance observed among enterococcal isolates.    Abstract  Antibiotic resistance represents a growing crisis in both human and veterinary medicine. We evaluated the use of antibiotic alternatives—heavy metals and essential oils—in beef cattle feeding, and their effects on Gram-negative and Gram-positive bacteria. In this randomized controlled field trial, we measured the impact of supplemental zinc and menthol on antibiotic resistance among commensal enteric bacteria of feeder cattle. Fecal suspensions were plated onto plain- and antibiotic-supplemented MacConkey and m- Enterococcus  agar for quantification of total and antibiotic-resistant  Escherichia coli  and  Enterococcus  spp., respectively. Temporal effects on overall  E. coli  growth were significant ( p  < 0.05), and menthol was associated with decreased growth on tetracycline-supplemented agar. Zinc was associated with significant increases in growth on erythromycin-supplemented m- Enterococcus  agar. Cattle fed zinc exhibited significantly higher levels of macrolide resistance among fecal enterococci isolates.

Effects of Zinc and Menthol-Based Diets on Co-Selection of Antibiotic Resistance among E. coli and Enterococcus spp. in Beef Cattle