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The gut microbiota in sows is important for the health of the host, and potential benefits may also be transferred to piglets during pregnancy. Therefore, systematic studies investigating the changes in the gut microbiota of sows are needed to elucidate the microbial compositions and functions. This study was conducted at 12 time points to investigate the temporal variations in gut microbiota on Days 27, 46, 64, 81, 100, and 113 during gestation (G) and Days 3, 5, 7, 10, 14, and 21 during lactation (L). Results suggested that the gut microbiota changed across the perinatal period with microbial function and abundance varying between the prenatal and postnatal periods. The alpha diversity was higher in the postnatal period than in the prenatal period. Thirty-eight genera were distributed between the two periods with Methanobrevibacter , Desulfovibrio , Akkermansia , and Turicibacte r being enriched in the prenatal period while Eubacterium , Actinobacillus , Paludibacter , Butyricimonas , Megasphaera , Succiniclasticum , Acidaminococcus , and Rummeliibacillus were enriched in the postnatal period. Analysis done at the different time points of the prenatal period suggested that Days 27 and 113 had more microbial biomarkers than other days. Bacteroidales , Bacteroidia , and Prevotella were enriched on the 27th day, while bacteria belonging to the Clostridium and Ruminococcaceae were enriched on the 113th day. On the other hand, Clostridiales , Ruminococcaceae , Clostridia , and unclassified Christensenellaceae were enriched three days after delivery. Predicted microbial KO functions were also more enriched on Day 27 of the gestation period and Day 3 of the lactation period. Random forest, a machine learning method, was used to identify the top five important genera of Megasphaera , Stenotrophomonas , Phyllobacterium , Catenibacterium , and Turicibacter , while the most important function was arginine and proline metabolism. These systematic results provide important information for the gut microbiota of sows.

The Dynamic Changes of Gut Microbiota during the Perinatal Period in Sows