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In this paper the synthesis of some 2-alkyl phenyl 5-substituted 1,3,4-thiadiazole is reported, Benzonitrile and Acetonitrile were treated with thiosemicarbazide in presence of trifluroacetic acid to give 2-alkyl/ aryl -5amino1,3,4thiadiazoles (1,2), which was treated with ethylchloroacetate in methanol to give Ethyl N-(5-alkyl/phenyl -1,3,4thiadiazole-2yl) glycinate (3,4), the resultant esters were converted to acid hydrazide (5,6) by their reaction with hydrazine hydrate in ethanol. Reaction of the hydrazides with benzaldehyde in ethanol gave hydrazones Synthesis of 2alkyl/phenyl -5-Substituted 1,3,4-Thiadiazoles. 28 (7,8). Thiadiazols (1,2) were treated with ethyl chloroformate, acetyl and benzoyl chloride or benzaldehyde/ p-methoxybenzaldehyde to give substituted thiadiazoles (17,18), (9-12) and (13-16) respectively. The structure of the synthesis compounds were confirmed by IR, UV. Spectra and physical means. Introduction Derivatives of 1,3,4-thiadiazole have been found to possess a wide spectrum of activities, thiadiazole were studied for anumber of pathological conditions including inflammation or hypertension. The synthesis of substituted 1,3,4-thiadiazole has attracted attention due to their application as anti-inflammatory, analgesic, antimicrobial antibacterial, anticonvulsant, anticancer, antifungal and plant growth regulating effect. Substituted 1,3,4-thiadiazoles were synthesis from thiosemicarbazide with carboxylic acid in concentrated sulfuric acid . Also substituted 1,3,4-thiadiazole was synthesized by using ferric chlorid in ethanol with substituted thiosemicarbazide . Whereas synthesis of 1,3,4-thiadiazol containing thiol group were . (21) with carbon disulphide obtained from reaction of thiosemicarbazid

Synthesis of 2- alkyl/phenyl -5-Substituted 1,3,4- Thiadiazoles