English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Integrons are genetic elements that capture and express antimicrobial resistance genes within arrays, facilitating horizontal spread of multiple drug resistance in a range of bacterial species. The aim of this study was to estimate prevalence for class 1, 2, and 3 integrons in Scottish cattle and examine whether spatial, seasonal or herd management factors influenced integron herd status. We used fecal samples collected from 108 Scottish cattle herds in a national, cross-sectional survey between 2014 and 2015, and screened fecal DNA extracts by multiplex PCR for the integrase genes  intI1, intI2 , and  intI3 . Herd-level prevalence was estimated [95% confidence interval (CI)] for  intI1  as 76.9% (67.8–84.0%) and  intI2  as 82.4% (73.9–88.6%). We did not detect  intI3  in any of the herd samples tested. A regional effect was observed for  intI1 , highest in the North East (OR 11.5, 95% CI: 1.0–130.9,  P  = 0.05) and South East (OR 8.7, 95% CI: 1.1–20.9,  P  = 0.04), lowest in the Highlands. A generalized linear mixed model was used to test for potential associations between herd status and cattle management, soil type and regional livestock density variables. Within the final multivariable model, factors associated with herd positivity for  intI1  included spring season of the year (OR 6.3, 95% CI: 1.1–36.4,  P  = 0.04) and watering cattle from a natural spring source (OR 4.4, 95% CI: 1.3–14.8,  P  = 0.017), and cattle being housed at the time of sampling for  intI2  (OR 75.0, 95% CI: 10.4–540.5,  P  < 0.001). This study provides baseline estimates for integron prevalence in Scottish cattle and identifies factors that may be associated with carriage that warrant future investigation.

High Prevalence and Factors Associated With the Distribution of the Integron intI1 and intI2 Genes in Scottish Cattle Herds