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Among swine genetic markers, the highly polymorphic swine leukocyte antigen (SLA) is one of the key determinants, associated with not only immune responses but also reproductive performance and meat quality. The objective of this study was to characterize the SLA class I and II diversities in the commercial pig populations. In this study, a total number of 158 pigs (126 gilts and 32 boars) were randomly selected from different breeding herds of five major pig-producing companies, which covered ~70% of Thai swine production. The results indicate that a moderate level of SLA diversity was maintained in the Thai swine population, despite the performance-oriented breeding scheme. The highly common SLA class I alleles were SLA-1 * 08:XX, SLA-2 * 02:XX, and SLA-3 * 04:XX at a combined frequency of 30.1, 18.4, and 34.5%, respectively, whereas DRB1 * 04:XX, DQB1 * 02:XX and DQA * 02:XX were the common class II alleles at 22.8, 33.3, and 38.6%, respectively. The haplotype Lr-32.0 (SLA-1 * 07:XX, SLA-2 * 02:XX, and SLA-3 * 04:XX) and Lr-0.23 (DRB1 * 10:XX, DQB1 * 06:XX, DQA *  01:XX) was the most common SLA class I and II haplotype, at 15.5 and 14.6%, respectively. Common class I and II haplotypes were also observed, which Lr-22.15 was the most predominant at 11.1%, followed by Lr-32.12 and Lr-4.2 at 10.8 and 7.9%, respectively. To our knowledge, this is the first report of SLA class I and II diversities in the commercial pigs in Southeast Asia. The information of the common SLA allele(s) in the population could facilitate swine genetic improvement and future vaccine design.

Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations