English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background:  Infected cattle sourced from districts with established foci for  Trypanosoma brucei rhodesiense  human African trypanosomiasis (rHAT) migrating to previously unaffected districts, have resulted in a significant expansion of the disease in Uganda. This study explores livestock movement data to describe cattle trade network topology and assess the effects of disease control interventions on the transmission of rHAT infectiousness.   Methods:  Network analysis was used to generate a cattle trade network with livestock data which was collected from cattle traders ( n  = 197) and validated using random graph methods. Additionally, the cattle trade network was combined with a susceptible, infected, recovered ( SIR ) compartmental model to simulate spread of rHAT ( R   o   1.287), hence regarded as “slow” pathogen, and evaluate the effects of disease interventions.   Results:  The cattle trade network exhibited a low clustering coefficient (0.5) with most cattle markets being weakly connected and a few being highly connected. Also, analysis of the cattle movement data revealed a core group comprising of cattle markets from both eastern (rHAT endemic) and northwest regions (rHAT unaffected area). Presence of a core group may result in rHAT spread to unaffected districts and occurrence of super spreader cattle market or markets in case of an outbreak. The key cattle markets that may be targeted for routine rHAT surveillance and control included Namutumba, Soroti, and Molo, all of which were in southeast Uganda. Using effective trypanosomiasis such as integrated cattle injection with trypanocides and spraying can sufficiently slow the spread of rHAT in the network.   Conclusion:  Cattle trade network analysis indicated a pathway along which  T. b. rhodesiense  could spread northward from eastern Uganda. Targeted  T. b. rhodesiense  surveillance and control in eastern Uganda, through enhanced public–private partnerships, would serve to limit its spread.

Livestock Network Analysis for Rhodesiense Human African Trypanosomiasis Control in Uganda