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Diarrheagenic  Escherichia coli  is the causative agent of diarrhea in infants and animals worldwide. Many isolated strains recovered from pigs with postweaning diarrhea are multidrug resistance (MDR), and hybrids of  E. coli  are potentially more virulent, as enterotoxigenic  E. coli  (ETEC)/Shiga-toxigenic  E. coli  (STEC) hybrids. Here, we used whole-genome sequencing to analyze clinical isolates of the five colistin-resistant  E. coli . The  E. coli  CAU15104, CAU15134, and CAU16060 belonged to ETEC/STEC hybrids, displaying the same serotype O3:H45 and sequence type ST4214. The  E. coli  CAU16175 and CAU16177 belonged to atypical enteropathogenic  E. coli  (aEPEC), display O4:H11 and O103:H2, ST29, and ST20, respectively. The  E. coli  CAU16175 carries six plasmids. An IncHI2-type plasmid, pCAU16175_1, harbors an IS 26 -enriched MDR region, which includes 16 antimicrobial-resistant genes. An IncFII-type plasmid, pCAU16175_3, harbors  mcr-1.1, tet (M), and  bla  TEM−1B , whereas  mcr-1.1  is located within a Tn 2  derivative. Our findings indicate that the ETEC/STEC strains of the O3:H45 serotype as well as the aEPEC strains of the O4:H11 and O103:H2 serotypes are associated with postweaning diarrhea in swine and that some of diarrheagenic  E. coli  contains IS 26 -enriched MDR region and the  mcr-1  gene located within a Tn 2  derivative on IncFII plasmid.

Genome Characterization of mcr-1–Positive Escherichia coli Isolated From Pigs With Postweaning Diarrhea in China