English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Pasteurella multocida  is a pathogenic microorganism that causes a variety of serious diseases in humans and animals worldwide. The global regulator gene,  fur , plays an important role in pathogenesis and regulates the virulence of many bacteria. Here, we identified a  fur  gene in  P. multocida  by complementing a  Salmonella  Choleraesuis Δ fur  mutant, and characterized a  fur  mutant strain of  P. multocida . The  P. multocida  Δ fur  mutant strain exhibited no significant differences in growth and outer membrane protein (OMP) profiles when the complemented strain was compared to the parent. Ducks were used as the model organism to determine the virulence and protection efficacy induced by Δ fur  mutant strain. Animal experiments showed that colonization by the mutant was decreased by oral infection of live Δ fur  mutant strain. The LD 50  of the ducks infected with the Δ fur  mutant was 146-fold higher than that of the ducks infected with the wild-type strain when administered through the oral route. Evaluation of the immunogenicity and protective efficacy of the Δ fur  mutant of  P. multocida  revealed strong serum IgY and bile IgA immune responses following oral inoculation with the Δ fur  strain. Ducks that were orally inoculated with the Δ fur  mutant strain demonstrated 62% protection efficacy against severe lethal challenge with the wild-type  P. multocida . This study provides new insights into  P. multocida  virulence and the potential use of an attenuated vaccine against  P. multocida .

Identification of Fur in Pasteurella multocida and the Potential of Its Mutant as an Attenuated Live Vaccine