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Fermentation metabolites of Diamond V Original XPC™ (XPC), a biological product derived from yeast fermentation, were evaluated for their ability to reduce the  Salmonella  Typhimurium population using an  in vitro  mixed anaerobic culture system containing cecal microbiota to simulate chicken hindgut conditions. Four different samples were prepared: anaerobic mixed culture containing (1) feed only, (2) cecal only (ceca were harvested from 42 days old broiler chickens), (3) feed and cecal contents, and (4) feed, cecal contents, and 1% XPC. Two experimental conditions were investigated: Group 1, in which the cecal content was added at the same time as a  S . Typhimurium marker strain and Group 2, in which the cecal content was preincubated for 24 h prior to the inoculation with the  S . Typhimurium marker strain. The mixed cultures were incubated anaerobically at 37°C, and the  S . Typhimurium marker strain was enumerated at 0, 24, and 48 h. Analysis of short chain fatty acids was also conducted for 24 h. In the Group 1 experiment, adding XPC did not exhibit significant reduction of  S . Typhimurium. However, the presence of XPC resulted in rapid reduction of  S . Typhimurium in Group 2.  S . Typhimurium was reduced from 6.81 log 10  CFU/ml (0 h) to 3.73 log 10  CFU/ml and 1.19 log 10  CFU/ml after 24 and 48 h, respectively. These levels were also 2.47 log 10  and 2.72 log 10  lower than the  S . Typhimurium level recovered from the control culture with feed and cecal contents, but without XPC. Based on these results, it appears that the ability of XPC to reduce  S . Typhimurium requires the presence of the cecal microbiota. Short chain fatty acid analysis indicated that acetate and butyrate concentrations of cultures containing XPC were twofold greater than the control cultures by 24 h of anaerobic growth. Results from the present study suggest that dietary inclusion of XPC may influence cecal microbiota fermentation and has the potential to reduce  Salmonella  in the cecum. Implications of these findings suggest that XPC may decrease preharvest levels of  Salmonella  in broilers and layers.

Reduction of Salmonella Typhimurium by Fermentation Metabolites of Diamond V Original XPC in an In Vitro Anaerobic Mixed Chicken Cecal Culture