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Objectives:  International studies suggest that males may be less likely to adhere to SARS-CoV-2 transmission mitigation efforts than females. However, there is a paucity of research in this field in the United States. The primary aim of this study was to explore the relationship of binary gender identity (female/male) with beliefs, attitudes, and pandemic-related practices in the early stages of the pandemic.   Methods:  This study is based on a cross-sectional, voluntary response survey. Patients who were tested for SARS-CoV-2 between March 5 and June 7, 2020 were invited to participate. All patients were tested within a large community healthcare system that serves patients through eight hospitals and hundreds of clinics across Washington State. Bivariate associations between gender and various demographics were tested using Chi-squared and Student's  t -tests. We examined associations between gender and pandemic-related beliefs, attitudes, and practices using multivariable logistic regression, accounting for potential confounding factors.   Results:  Females were more likely than males to agree that they (aOR = 1.51, 95% CI 1.14–2.00) or their families (aOR = 1.75, 95% CI 1.31–2.33) were threatened by SARS-CoV-2, or that their own behavior could impact transmission (aOR = 2.17, 95% CI 1.49–3.15). Similarly, females were more likely to agree that social distancing (aOR = 1.72, 95% CI 1.19–2.46), handwashing (aOR = 3.27, 95% CI 2.06–5.21), and masking (aOR = 1.41, 95% CI 1.02–1.94) were necessary to slow SARS-CoV-2 spread. Females were significantly less likely to visit outside of their social distancing circle (aOR = 0.62, 95% CI 0.47–0.81), but among those who did, practices of social distancing (aOR = 1.41, 95% CI 0.89–2.23), remaining outdoors (aOR = 0.89, 95% CI 0.56–1.40), and masking (aOR = 1.19, 95% CI 0.74–1.93) were comparable to males, while females practiced handwashing more than males (aOR = 2.11, 95% CI 1.33–3.34).   Conclusions:  Our study suggests that gender disparate beliefs, attitudes, and practices existed in the early stages of the SARS-CoV-2 pandemic. Efforts should be tailored to encourage males to engage with mitigation efforts in ongoing pandemic-related public health campaigns.

Gender Discrepancies in SARS-CoV-2 Pandemic Related Beliefs, Attitudes, and Practices