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Background:  The coronavirus disease 2019 (COVID-19)-related quarantine has had unique psychological challenges for medical students, particularly loneliness. In this study, we demonstrated the patterns and predictors of loneliness in medical students since post-lockdown to new normal with COVID-19.   Methods:  A convenience sampling method was used in this study. Face-to-face online questionnaires of UCLA Loneliness Scale and psychological characteristics scales were completed by 1,478 participants. Latent profile analysis and multinominal logistic regressions were performed.   Results:  Three latent profile models were identified in this study: low loneliness (52.3%), interpersonal sensitivity loneliness (3.5%), and high loneliness (44.1%). Sophomore (Est = 1.937;  p  < 0.05) and junior students (Est = 2.939;  p  < 0.05), neuroticism (Est = 2.475;  p  < 0.05), high arousal symptoms (Est = 2.618;  p  < 0.01), and the quality of support from friends (Est = 2.264;  p  < 0.05) were the risk factors for high loneliness profile. In addition, sophomore (Est = 2.065;  p  < 0.05) and junior students (Est = 2.702;  p  < 0.01), openness (Est = 2.303;  p  < 0.05), and conscientiousness personality (Est = −2.348;  p  < 0.05) were the predictors of an interpersonal sensitive loneliness profile. Good peer relationship (Est = −2.266;  p  < 0.05) and other support (Est = −2.247;  p  < 0.05) were protective factors for low loneliness profile.   Limitations:  Participants were selected from one medical university; the generalizability is limited.   Conclusions:  Timely loneliness-focused interventions should be targeted on the different profiles and predictors of loneliness in medical students.

The Patterns and Predictors of Loneliness for the Chinese Medical Students Since Post-Lockdown to New Normal With COVID-19