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Background  A low intention of professional help seeking hinders the effective treatment of depression. The factors are from the perspectives of the social, family, and individual; however, an understanding of how they interact to predict professional help-seeking intention (PHSI) is not clear.    Objectives  The objectives of the study was to investigate PHSI toward depression in a Chinese community-dwelling population and construct a predictive model of the PHSI to explore the various factors involved.    Methods  Stratified random sampling and Kish table methods were used to identify 2,000 community residents. Participants completed a series of questionnaires to measure general characteristics, PHSI, professional help-seeking attitude, depression stigma, depression knowledge, family function, and depression symptoms. Analyses included descriptive statistics and Pearson correlation analysis using SPSS 26.0 and a Structural Equation Model using Amos 22.0.    Results  The score of the PHSI was 14.92 ± 9.574. Professional help-seeking attitude ( r  = 0.291,  p  &amp;lt; 0.001) and depression knowledge ( r  = 0.077,  p  = 0.002) were positively related to PHSI, while a negative correlation was found between stigma ( r  = −0.149,  p  &amp;lt; 0.001) and PHSI. The model of the PHSI indicated a good fit with a CMIN/DF = 2.740 and RESEA = 0.032. The total effect of the influencing factors on the PHSI was listed in the following order: professional help-seeking attitude (0.676) &amp;gt; stigma (−0.143) &amp;gt; depression knowledge (0.088) &amp;gt; depression symptoms (−0.009) &amp;gt; family function (0.005). The total effect of depression knowledge on PHSI included a direct negative effect (Beta = −0.266,  p  &amp;lt; 0.001) and an indirect positive effect (0.354) through professional help-seeking attitude and stigma. Also, depression knowledge was negatively associated with stigma (Beta = −0.153,  p  &amp;lt; 0.001). Depression symptoms were negatively associated with family function (Beta = −0.282,  p  &amp;lt; 0.001), depression knowledge (Beta = −0.252,  p  &amp;lt; 0.001), and stigma (Beta = −0.102,  p  &amp;lt; 0.001), indicating that people with less severe depression symptoms had good family function, depression knowledge, and higher stigma. Family function contributed a positive effect on depression knowledge directly (Beta = 0.145,  p  &amp;lt; 0.001) and a totally positive effect (0.033) on stigma.    Conclusion  The PHSI toward depression is low among Chinese community residents. Professional help-seeking attitude, depression knowledge, and family functioning were facilitators of PHSI, and stigma and the severity of depression symptoms were barriers to PHSI. This study provides reference for the development of policies and guidelines to promote community residents to actively seek professional mental health help. Future policies can focus on multicollaboration among the government, mental health services, and families to increase the mental health resources, improve family functioning, enhance mental health literacy (MHL) of the public, and reduce depression stigma to ease the burden of this mental health issue.

Predictors of Professional Help-Seeking Intention Toward Depression Among Community-Dwelling Populations: A Structural Equation Modeling Analysis