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Background:  It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI).    Methods:  Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/amygdala (AMG)/hippocampus (HP)/parahippocampal gyrus (PHG) FC according to the different levels of resilience scale.    Results:  Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG ( P  < 0.05, Bonferroni corrected), between the right inferior OFG and left PHG ( P  < 0.05, Bonferroni corrected), and between the right middle OFG and left PHG (false discovery rate < 0.05).    Conclusion:  Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.

Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment