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Both chronic stress (1) and anxiety disorders (2) are risk factors for developing alcohol use disorders (AUDs). Conversely, chronic alcohol consumption can increase anxiety via a rebound effect and acute withdrawal symptoms, thus contributing to anxiety-related development of AUDs and their maintenance (3). As such, there is a rationale and growing interest in developing medications with anti-stress and/or anxiolytic properties as putative treatments for AUDs. To this end, animal models that approximate or are relevant to human conditions of chronic stress and anxiety are relevant to test the effect of potential medications on alcohol-seeking behaviors.

Increased Ethanol Consumption Following Chronic Psychosocial Stress: Do Oxytocin and Baclofen Hold any Therapeutic Promise?