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MicroRNAs (miRNAs), important posttranscriptional regulators of gene expression, play a crucial role in plant growth and development. A single miRNA can regulate numerous target genes, making the determination of its function and interaction with targets challenging. We identified PtomiR403b target to  PtoGT31B-1 , which encodes a galactosyltransferase responsible for the biosynthesis of cell wall polysaccharides. We performed an association study and epistasis and Mendelian randomization (MR) analyses to explore how the genetic interaction between  PtoMIR403b  and its target  PtoGT31B-1  underlies wood formation. Single nucleotide polymorphism (SNP)-based association studies identified 25 significant associations ( P  < 0.01,  Q  < 0.05), and  PtoMIR403b  and  PtoGT31B-1  were associated with five traits, suggesting a role for PtomiR403b and  PtoGT31B-1  in wood formation. Epistasis analysis identified 93 significant pairwise epistatic associations with 10 wood formation traits, and 37.89% of the SNP-SNP pairs indicated interactions between  PtoMIR403b  and  PtoGT31B-1 . We performed an MR analysis to demonstrate the causality of the relationships between SNPs in  PtoMIR403b  and wood property traits and that  PtoMIR403b  modulates wood formation by regulating expression of  PtoGT31B-1 . Therefore, our findings will facilitate dissection of the functions and interactions with miRNA-targets.

frontiers in plant science

Association Study and Mendelian Randomization Analysis Reveal Effects of the Genetic Interaction Between PtoMIR403b and PtoGT31B-1 on Wood Formation in Populus tomentosa