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The phytohormone Abscisic acid (ABA) regulates plant growth, development, and responses to abiotic stresses, including senescence, seed germination, cold stress and drought. Several kinds of researches indicate that exogenous ABA can enhance artemisinin content in  A. annua . Some transcription factors related to ABA signaling are identified to increase artemisinin accumulation through activating the artemisinin synthase genes. However, no prior study on ABA transporter has been performed in  A. annua . Here, we identified a pleiotropic drug resistance (PDR) transporter gene  AaPDR4/AaABCG40  from  A. annua .  AaABCG40  was expressed mainly in roots, leaves, buds, and trichomes. GUS activity is primarily observed in roots and the vascular tissues of young leaves in  proAaABCG40 :  GUS  transgenic  A. annua  plants. When  AaABCG40  was transferred into yeast AD12345678, yeasts expressing  AaABCG40  accumulated more ABA than the control. The  AaABCG40  overexpressing plants showed higher artemisinin content and stronger drought tolerance. Besides, the expression of  CYP71AV1  in OE- AaABCG40  plants showed more sensitivity to exogenous ABA than that in both wild-type and i AaABCG40  plants. According to these results, they strongly suggest that AaABCG40 is involved in ABA transport in  A. annua .

AaABCG40 Enhances Artemisinin Content and Modulates Drought Tolerance in Artemisia annua