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Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion from neuroendocrine cells. Thought to be exclusive to animals, synaptotagmins have recently been characterized in  Arabidopsis thaliana , in which they comprise a five gene family. Using infectivity and leaf-based functional assays, we have shown that  Arabidopsis  SYTA regulates endocytosis and marks an endosomal vesicle recycling pathway to regulate movement protein-mediated trafficking of the Begomovirus  Cabbage leaf curl virus  (CaLCuV) and the Tobamovirus  Tobacco mosaic virus  (TMV) through plasmodesmata (Lewis and Lazarowitz,  2010 ). To determine whether SYTA has a central role in regulating the cell-to-cell trafficking of a wider range of diverse plant viruses, we extended our studies here to examine the role of SYTA in the cell-to-cell movement of additional plant viruses that employ different modes of movement, namely the Potyvirus  Turnip mosaic virus  (TuMV), the Caulimovirus  Cauliflower mosaic virus  (CaMV) and the Tobamovirus  Turnip vein clearing virus  (TVCV), which in contrast to TMV does efficiently infect Arabidopsis. We found that both TuMV and TVCV systemic infection, and the cell-to-cell trafficking of the their movement proteins, were delayed in the Arabidopsis Col-0  syta-1  knockdown mutant. In contrast, CaMV systemic infection was not inhibited in  syta-1 . Our studies show that SYTA is a key regulator of plant virus intercellular movement, being necessary for the ability of diverse cell-to-cell movement proteins encoded by Begomoviruses (CaLCuV MP), Tobamoviruses (TVCV and TMV 30K protein) and Potyviruses (TuMV P3N-PIPO) to alter PD and thereby mediate virus cell-to-cell spread.

The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses