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Background:  In addition to the cardiovascular and renal systems, the gastrointestinal tract also contains angiotensin ATR 1a , ATR 1b , and ATR 2 . We previously observed that the 2Kidney-1Clip hypertension model elicits physical exercise and gastrointestinal dysmotility, which is prevented by renin-angiotensin system blockers. Here, we investigate the effect of physical exercise on inflammation, stress biomarkers, and angiotensin II receptors in the duodenum of 2K1C rats.   Methods:  Arterial hypertension was induced by the 2K1C surgical model. The rats were allocated in Sham, 2K1C, or 2K1C+Exercise groups. One week after surgery, they were submitted to a physical exercise protocol (running 5x/week, 60min/day). Next, we assessed their intestinal contractility, cytokine levels (TNF-α, IL-1β, and IL-6), oxidative stress levels (MPO, GSH, MDA, and SOD), and the gene expression of angiotensin receptors (ATR 1A , ATR 1B , and ATR 2 ).   Results:  In comparison with the Sham group, the 2K1C arterial hypertension decreased ( p <0.05) the intestinal contractility. In comparison with 2K1C, the 2K1C+Exercise group exhibited lower ( p <0.05) MPO activity (22.04±5.90 vs. 78.95±18.09 UMPO/mg tissue) and higher ( p <0.05) GSH concentrations in intestinal tissues (67.63±7.85 vs. 31.85±5.90mg NPSH/mg tissue). The 2K1C+Exercise group showed lower ( p <0.05) cytokine levels in the intestine than 2K1C rats. In comparison with the Sham group, the 2K1C+Exercise rats showed higher ( p <0.05) gene expression of ATR 2  in the duodenum.   Conclusion:  2K-1C hypertension elicits an oxidative stress and inflammation process in the duodenum. Physical exercise modulates the expression twice as much of ATR2 receptors, suggesting possible anti-inflammatory and antioxidant effects induced by exercise.

Moderate Physical Exercise Activates ATR2 Receptors, Improving Inflammation and Oxidative Stress in the Duodenum of 2K1C Hypertensive Rats