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Background and Aims:  The negative effects of chronic low-level inflammation on adipose tissue physiology have been extensively demonstrated, whereas the effects of acute inflammation are less studied. Here, we aimed to investigate the effects of sepsis-induced acute inflammation on gene expression markers of brown and white adipose tissue functionality.   Methods:  Brown adipose tissue (BAT) and perirenal white adipose tissue (prWAT) gene expression markers were analyzed in cecal ligation and puncture (CLP)-induced sepsis mice model.   Results:  CLP-induced sepsis attenuated expression of adipogenesis-related genes, in parallel to increased  Tnf, Il6 , and  Ltf  gene expression in prWAT. In contrast, CLP-induced sepsis resulted in increased expression of pro-inflammatory genes ( Il6, Ltf , and  Lbp ) in BAT, without affecting expression of genes encoding for thermogenic activity.   Conclusion:  Sepsis promotes both prWAT and BAT inflammation, associated with reduced adipogenesis-related gene expression in prWAT, without significant effects on BAT thermogenic genes.

Cecal Ligation and Puncture-Induced Sepsis Promotes Brown Adipose Tissue Inflammation Without Any Impact on Expression of Thermogenic-Related Genes