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Oxytocin (Oxt), osteocalcin (Ost), and NGF/BDNF have a role in bone homeostasis, reproduction, and cognition. Oxt/Ost is required for muscle repair. We investigated gene response of muscle and the inter-organ communication following cold stress (CS). The mRNA quantity of  Ngf ,  Ost ,  Oxt ,  Bdnf ,  p75ntr ,  Ntrk1 ,  Gprc6a ,  Oxtr ,  Ntrk2 ,  UCP1 , and  Il-6  genes in bone, brain, soleus (SOL), and  tibialis anterior  (TA) muscles from adult mice following CS were investigated. The myosin heavy-chain  Mhc2b ,  Mhc1 ,  Mhc2x , and  Mhc2a  gene expression were investigated. Mice were maintained at  T  = 23°C or 4°C for 6 h and 5-days (5d). CS mice did not show signs of muscle degeneration. An upregulation of  Ucp1  and  Ngf  genes by 2 and 1.5 folds, respectively, in TA after 6 h CS and  Ntrk1  by 4 and 22 folds in SOL muscle after 6 h and 5d CS, respectively, was observed; while after 6 h CS  p75Ntr  was downregulated in either muscle.  Bdnf  was unaffected, while after 5d CS  Ntrk2  was upregulated in TA.  Ost  was downregulated in SOL by 0.9-folds at 5d. Following 5d CS,  Oxtr  and  Il-6  genes were upregulated, respectively, by 1 and 1.5 folds in SOL. A downregulation of  Mhc2b , respectively, by 0.96 and 0.88-folds after 6 h and 5d CS in SOL and  Mhc2a  was also downregulated by 0.88-fold after 5d CS in TA.  Mhc1  and  Mhc2x  were not affected. Changes in the expression levels of genes in TA and SOL muscles, bone, and brain following CS were regulated by IL6 and Oxt. CS potentiates the slow-twitch phenotype of SOL which is in line with the metabolic need of this muscle, and the potentiation of the slow-twitch phenotype in TA. Oxt and IL6 coordinate a phenotype-dependent tonic effect of slow-twitch muscle and Oxt regulates the inter-organ interaction between brain and SOL muscle. Muscle tropism is maintained by NGF signaling following CS.

Oxytocin/Osteocalcin/IL-6 and NGF/BDNF mRNA Levels in Response to Cold Stress Challenge in Mice: Possible Oxytonic Brain-Bone-Muscle-Interaction