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This study evaluated the effectiveness of an innovative strategy which combined low-frequency ultra sound (LOFU) with high-intensity interval training (HIIT) to improve physical fitness and promote body fat loss in overweight sedentary women. A placebo controlled, parallel group randomized experimental design was used to investigate the efficacy of a 2-week combined LOFU and HIIT program (3 sessions per week). Participants were allocated into either the Experimental HIIT group (HIIT EXP ,  n  = 10) or Placebo HIIT group (HIIT PLA ,  n  = 10). Baseline exercise testing (maximal oxygen uptake, lower limb strength and substrate oxidation test), dietary assessment, anthropometric measures and blood sampling were completed in week 1 and repeated in week 4 to determine changes following the program (Post-HIIT). During each training session, the HIIT EXP  and HIIT PLA  groups wore a non-thermal diffuse ultrasound belt. However, the belt was only switched on for the HIIT EXP  group. Delta change scores were calculated for body weight, body fat percentage (Fat%), muscle mass,V  .    O 2  max , hip and waist circumferences, and all lipid variables from Baseline to Post-HIIT. Statistical analysis was completed using a repeated-measures factorial analysis of variance by group (HIIT PLA  and HIIT EXP ) and time (Baseline and Post-HIIT). Results showed significant improvements in maximal oxygen uptake (HIIT EXP ; Baseline 24.7 ± 5.4 mL kg –1  min –1 , Post-HIIT 28.1 ± 5.5 mL kg –1  min –1  and HIIT PLA ; Baseline 28.4 ± 5.9 mL kg –1  min –1 , Post-HIIT 31.4 ± 5.5 mL kg –1  min –1 ) for both groups. Significant decreases in Fat% (HIIT EXP ; Baseline 32.7 ± 3.2%, Post-HIIT 28.9 ± 3.5% and HIIT PLA ; Baseline 28.9 ± 3.5%, Post-HIIT 28.9 ± 3.4% kg), waist circumference (HIIT EXP ; Baseline 95.8 ± 9.6 cm, Post-HIIT 89.3 ± 8.9 cm and HIIT PLA ; Baseline 104.3 ± 3.5 cm, Post-HIIT 103.6 ± 3.4 cm) and triglycerides (HIIT EXP ; −29.2%, HIIT PLA ; −6.7%) were observed in the HIIT EXP  group only. These results show that HIIT combined with LOFU was an effective intervention to improve body composition, lipid profile, and fitness. This combined strategy allowed overweight, sedentary women to achieve positive health outcomes in as little as 2 weeks.

frontiers in physiology

Two Weeks of High-Intensity Interval Training in Combination With a Non-thermal Diffuse Ultrasound Device Improves Lipid Profile and Reduces Body Fat Percentage in Overweight Women