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We investigated if the same isometric preconditioning protocol (IPP) attenuates the magnitude of muscle damage induced by different maximal eccentric exercise protocols in the elbow flexors. Sixty-four untrained men were assigned to either two experimental or two control groups. Participants in the experimental groups performed an IPP prior to either slow (60°·s −1  – ISO + ECC-S) or fast (180°·s −1  – ISO + ECC-F) maximal eccentric contractions (MaxECC). Subjects in the control groups performed slow (ECC-S) or fast (ECC-F) MaxECC without IPP. Maximal isokinetic concentric torque (MVC), muscle soreness (SOR), and muscle thickness (MT) were assessed before, immediately after, and 1–4 days following the MaxECC. Significant ( p  < 0.05) group vs. time interactions were found for MVC ( F  = 4,517), SOR ( F  = 6,318), and MT ( F  = 1,863). The ECC-S group presented faster ( p  < 0.05) recovery of MVC and MT and less ( p  < 0.05) SOR at 96 h post-MaxECC compared with ECC-F group. No significant differences in MVC and MT were found between ECC-S and ECC-F groups following MaxECC. The ISO + ECC-S group showed faster ( p  < 0.05) recovery of MVC and SOR compared to the ECC-S group. No significant differences were evident between ISO + ECC-S and ECC-S in any variable. The ISO + ECC-F group showed faster ( p  < 0.05) recovery of all assessed variables compared with the ECC-F group. MVC was greater ( p  < 0.05) at 48–72 h, and SOR was less ( p  < 0.05) at 48–96 h in the ISO + ECC-F compared to the ECC-F group. No significant differences were evident between ISO + ECC-S and ISO + ECC-F for any variable. These results show that the IPP accelerated recovery of MVC and SOR for the slow-eccentric exercise condition and attenuated strength loss and SOR in addition to faster recovery of all assessed variables for the fast-eccentric exercise condition. Therefore, the IPP can be used as a strategy to attenuate and accelerate recovery of muscle damage induced by different-velocity eccentric exercises, resulting in greater protection against muscle damage induced by faster velocity.

Protective Effect Conferred by Isometric Preconditioning Against Slow- and Fast-Velocity Eccentric Exercise-Induced Muscle Damage