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The aim of this study was to examine the effects of  Lactobacillus brevis  on the microbial community and serum metabolome in colitis induced by dextran sulfate sodium (DSS). ICR mice were randomly distributed into three treatment groups: (i)  L. brevis  treatment alone (control), (ii) DSS administration alone, and (iii) treatment with  L. brevis  and DSS. Our results demonstrate that  L. brevis  treatment significantly alleviated DSS-induced body weight loss and colon inflammation. In addition, LC-MS analysis of serum metabolites revealed that  L. brevis  treatment increased the serum level of metabolites against inflammatory responses or oxidative stressors caused by DSS in the murine model. By detecting colonic microbiota,  L. brevis  increased colonic microbial diversity after challenging with DSS, and increased the relative abundance of Alloprevotella at genus, but Bacteroidales was reduced ( P  < 0.05). These result indicated that  L. brevis  could lower the severity of colitis induced by DSS via improving reprogramming the serum metabolome and intestinal microbiota. These findings suggest that the probiotic  L. brevis  may prevent tissue damage from colitis.

Lactobacillus brevis Alleviates DSS-Induced Colitis by Reprograming Intestinal Microbiota and Influencing Serum Metabolome in Murine Model