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Pesticide resistance is a serious problem that poses a major challenge to pest control. One of the most potent resistance mechanisms is the overexpression of genes coding for detoxification enzymes. The expression of detoxification genes is regulated by a series of transcription factors. Previous studies have revealed that the increased expression of detoxification genes contributes to the insecticide tolerance of  Bactrocera dorsalis.  Our objective was thus to identify the transcription factors involved in this process. Temporal expression profiles showed that the transcription factor  MafB  and detoxification genes were expressed highly in the fat body. Further analysis showed that the expression of  MafB ,  GSTz2 , and  CYP473A3  was induced by abamectin. Disruption of the  MafB  transcription factor through RNA interference decreased the transcript levels of  GSTz2  and  CYP473A3  and increased the susceptibility to abamectin significantly. Direct silencing of the expression of  GSTz2  also increased susceptibility to abamectin, while  CYP473A3  did not. In conclusion, these results suggest that the expression of  GSTz2  and  CYP473A3  was regulated by the transcription factor  MafB , and the up-regulation of  GSTz2  via  MafB  decreased the susceptibility of  B. dorsalis  to abamectin.

The Transcription Factor MafB Regulates the Susceptibility of Bactrocera dorsalis to Abamectin via GSTz2