English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background:  Nrg4 expression has been linked to brown adipose tissue activity and browning of white adipocytes in mice. Here, we aimed to investigate whether these observations could be translated to humans by investigating  NRG4  mRNA and markers of brown/beige adipocytes in human visceral (VAT) and subcutaneous adipose tissue (SAT). We also studied the possible association of  NRG4  with insulin action.   Methods:  SAT and VAT  NRG4  and markers of brown/beige ( UCP1, UCP3, and TMEM26 )-related gene expression were analyzed in two independent cohorts ( n  = 331 and  n  = 59). Insulin resistance/sensitivity was measured using HOMA IR  and glucose infusion rate during euglycemic hyperinsulinemic clamp.   Results:  In both cohort 1 and cohort 2,  NRG4  and thermogenic/beige-related gene expression were significantly increased in VAT compared to SAT. Adipogenic-related genes followed an opposite pattern. In cohort 1, VAT  NRG4  gene expression was positively correlated with BMI and expression of  UCP1, UCP3, TMEM26 , and negatively with adipogenic ( FASN, PPARG , and  SLC2A4 )- and inflammatory ( IL6 and IL8 )-related genes. In SAT,  NRG4  gene expression was negatively correlated with HOMA IR  and positively with  UCP1  and  TMEM26  gene expression. Multiple linear regression analysis revealed that expression of  TMEM26  gene was the best predictor of  NRG4  gene expression in both VAT and SAT. Specifically,  NRG4  and  TMEM26  gene expression was significantly increased in VAT, but not in SAT stromal vascular fraction cells ( p  < 0.001). In cohort 2, the significant association between  NRG4  and  TMEM26  gene expression in both VAT and SAT was confirmed, and SAT  NRG4  gene expression also was positively correlated with insulin action and the expression of  UCP1 .   Conclusion:  Current findings suggest  NRG4  gene expression as a novel marker of beige adipocytes in human adipose tissue.

Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue