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Purpose:  African American individuals are more prone to salt-sensitive hypertension than Caucasian individuals. Small changes in serum sodium (Na + ) result in increased blood pressure (BP). However, it remains unclear if there are racial differences in BP responsiveness to increases in serum Na + . Therefore, the purpose of this investigation was to determine if African American adults have altered BP responsiveness to acute changes in serum Na +  compared to Caucasian adults.   Methods:  We measured beat-by-beat BP, serum Na + , plasma renin activity (PRA), angiotensin II (Ang II), and aldosterone (Aldo) during a 60-min 3% NaCl infusion (hypertonic saline infusion, HSI) in 39 participants (19 African Americans, age: 23 ± 1, 20 Caucasians, age: 25 ± 1). Data reported as African American vs. Caucasian cohort, mean ± SEM.   Results:  Baseline BP and serum Na +  were similar between groups and increased during HSI in both African American and Caucasian participants ( p  < 0.01). However, the peak change in serum Na +  was greater in African American participants (Δ5.8 ± 0.34 vs. Δ4.85 ± 0.38 mmol/L,  p  = 0.03). There was a significant group effect ( p  = 0.02) and an interaction between race and serum Na +  on systolic BP ( p  = 0.02). Larger categorical changes in serum Na +  corresponded to changes in systolic BP ( p  < 0.01) and African American participants demonstrated greater systolic BP responses for a given categorical serum Na +  increase ( p  < 0.01). Baseline Aldo was lower in African American adults (7.2 ± 0.6 vs. 12.0 ± 1.9 ng/dL,  p  = 0.03), there was a trend for lower baseline PRA (0.59 ± 0.9 vs. 1.28 ± 0.34 ng/mL/h,  p  = 0.07), and baseline Ang II was not different (14.2 ± 1.8 vs. 18.5 ± 1.4 pg/mL,  p  = 0.17). PRA and Aldo decreased during the HSI ( p  ≤ 0.01), with a greater decline in PRA (Δ–0.31 ± 0.07 vs. Δ–0.85 ± 0.25 ng/mL/h,  p  < 0.01) and Aldo (Δ–2.5 ± 0.5 vs. Δ–5.0 ± 1.1 ng/dL,  p  < 0.01) in Caucasian participants. However, the racial difference in PRA ( p  = 0.57) and Aldo ( p  = 0.59) reduction were no longer significant following baseline covariate analysis.  Conclusion:  African American individuals demonstrate augmented serum Na +  to an acute hypertonic saline load and greater systolic BP responsiveness to a given serum Na + . The altered BP response may be attributable to lower basal PRA and Aldo and a subsequently blunted RAAS response during the HSI.

Acute NaCl Loading Reveals a Higher Blood Pressure for a Given Serum Sodium Level in African American Compared to Caucasian Adults