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Background:  We have previously shown an accelerated recovery from muscle fatigue in men challenged by prolonged exercise after oral deep ocean minerals (DOM) supplementation. Here, we hypothesized a decrease in eccentric exercise-induced muscle inflammation in rats regularly consuming DOM-containing drinks (hardness 600 mg/L and fructose 11%).   Methods:  Forty-seven male Sprague Dawley rats were randomized into 4 groups: Control (C,  N  = 12), Fructose (F,  N  = 12), Fructose+Exercise (FE,  N  = 12), and Fructose+Exercise+DOM (FED,  N  = 11). Since fructose is a commonly used ingredient in beverages, 11% of fructose was added as a vehicle of the study. Soleus muscles of rats were analyzed 24 h after an acute bout of downhill running following 9 weeks of DOM supplementation.   Results:  Leukocyte infiltration and TNF-α mRNA of muscle in the FE group were 5 times and 4 times greater the F group, respectively, ( P  < 0.05). Both markers in the FED group were significantly lower than those in the FE group ( P  < 0.05). IL-10 mRNA of muscle in the F group was >eight fold greater than the C group ( P  < 0.05). The reduced glutathione (GSH) of muscle in the F group was 34% lower than that in the C group ( P  < 0.05). However, GSH levels were similar for the C and FED groups.   Conclusion:  Prolonged fructose supplementation modulates inflammatory balance of rat skeletal muscle. The results of the study suggest that DOM can minimize eccentric exercise-induced inflammatory cytokine responses in rat skeletal muscle.

Deep Ocean Minerals Minimize Eccentric Exercise-Induced Inflammatory Response of Rat Skeletal Muscle