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The impact of disruption of adipokinetic hormone (AKH) signaling was studied during aging in  Drosophila  in a sexually dimorphic manner. A mutant ( Akh  1 ) producing a non-functional AKH peptide was compared with isogenized wild-type controls ( w  1118 ), and  Akh -rescue line where AKH was ectopically expressed in the mutant background ( EE-Akh ). Longevity, fecundity, and locomotor activity rhythms remained unaffected by lack of AKH signaling. While the strength of rhythms declined in general with age across all fly lines tested this was more so in case of  Akh  1  flies. Negative geotaxis was significantly impaired in  Akh  1  flies. Only young  Akh  1  flies of both sexes and old  Akh  1  females showed significantly higher body weight compared to age-matched iso-control flies (except in case of  EE-Akh ). Expression of genes involved in energy homeostasis and aging indicated that  dTOR  and  Akt  expression were elevated in  Akh  1  flies compared to other genotypes, whereas  AMPK  and  dFoxO  expression levels were significantly reduced. Multivariate analysis of the distribution of lipid species revealed a significant accumulation of specific diglyceride (DG) and triglyceride (TG) lipid species, irrespective of sex, attributable in part due to lack of AKH. Moreover, irrespective of lack of AKH, older flies of all genotypes accumulated TGs. Taken together, the results strongly suggest that disruption of AKH has very subtle effects on physiology, behavior and lipid status during aging.

Disruption of Adipokinetic Hormone Mediated Energy Homeostasis Has Subtle Effects on Physiology, Behavior and Lipid Status During Aging in Drosophila