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The disproportionate body mass and leg length of Achondroplasic individuals may affect their net oxygen consumption (    V  ͘    O 2 ) and metabolic cost (C) when walking at running compared to those of average stature (controls). The aim of this study was to measure submaximalV  ͘    O 2  and C during a range of set walking speeds (SWS; 0.56 – 1.94 m⋅s -1 , increment 0.28 m⋅s -1 ), set running speeds (SRS; 1.67 – 3.33 m⋅s -1 , increment 0.28 m⋅s -1 ) and a self-selected walking speed (SSW).V  ͘    O 2  and C was scaled to total body mass (TBM) and fat free mass (FFM) while gait speed was scaled to leg length using Froude’s number (Fr). AchondroplasicV  ͘    O 2TBM  andV  ͘    O 2FFM  were on average 29 and 35% greater during SWS ( P  < 0.05) and 12 and 18% higher during SRS ( P  < 0.05) than controls, respectively. Achondroplasic C TBM  and C FFM  were 29 and 33% greater during SWS ( P  < 0.05) and 12 and 18% greater during SRS ( P  < 0.05) than controls, respectively. There was no difference in SSWV  ͘    O 2TBM  orV  ͘    O 2FFM  between groups ( P  > 0.05), but C TBM  and C FFM  at SSW were 23 and 29% higher ( P  < 0.05) in the Achondroplasic group compared to controls, respectively.V  ͘    O 2TBM  andV  ͘    O 2FFM  correlated with Fr for both groups ( r  = 0.984 – 0.999,  P  < 0.05). Leg length accounted for the majority of the higherV  ͘    O 2TBM  andV  ͘    O 2FFM  in the Achondroplasic group, but further work is required to explain the higher Achondroplasic C TBM  and C FFM  at all speeds compared to controls.   New and Noteworthy:  There is a leftward shift of oxygen consumption scaled to total body mass and fat free mass in Achondroplasic adults when walking and running. This is nullified when talking into account leg length. However, despite these scalars, Achondroplasic individuals have a higher walking and metabolic cost compared to age matched non-Achondroplasic individuals, suggesting biomechanical differences between the groups.

The Oxygen Consumption and Metabolic Cost of Walking and Running in Adults With Achondroplasia