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In experimental elastase-induced emphysema, mechanical ventilation with variable tidal volumes (V T ) set to 30% coefficient of variation (CV) may result in more homogenous ventilation distribution, but might also impair right heart function. We hypothesized that a different CV setting could improve both lung and cardiovascular function. Therefore, we investigated the effects of different levels of V T  variability on cardiorespiratory function, lung histology, and gene expression of biomarkers associated with inflammation, fibrogenesis, epithelial cell damage, and mechanical cell stress in this emphysema model. Wistar rats ( n  = 35) received repeated intratracheal instillation of porcine pancreatic elastase to induce emphysema. Seven animals were not ventilated and served as controls (NV). Twenty-eight animals were anesthetized and assigned to mechanical ventilation with a V T  CV of 0% (BASELINE). After data collection, animals ( n  = 7/group) were randomly allocated to V T  CVs of 0% (VV 0 ); 15% (VV 15 ); 22.5% (VV 22.5 ); or 30% (VV 30 ). In all groups, mean V T  was 6 mL/kg and positive end-expiratory pressure was 3 cmH 2 O. Respiratory system mechanics and cardiac function (by echocardiography) were assessed continuously for 2 h (END). Lung histology and molecular biology were measured post-mortem. VV 22.5  and VV 30  decreased respiratory system elastance, while VV 15  had no effect. VV 0 , VV 15 , and VV 22.5 , but not VV 30 , increased pulmonary acceleration time to pulmonary ejection time ratio. VV 22.5  decreased the central moment of the mean linear intercept (D2 of Lm) while increasing the homogeneity index (1/β) compared to NV (77 ± 8 μm vs. 152 ± 45 μm; 0.85 ± 0.06 vs. 0.66 ± 0.13,  p  < 0.05 for both). Compared to NV, VV 30  was associated with higher interleukin-6 expression. Cytokine-induced neutrophil chemoattractant-1 expression was higher in all groups, except VV 22.5 , compared to NV. IL-1β expression was lower in VV 22.5  and VV 30  compared to VV 0 . IL-10 expression was higher in VV 22.5  than NV. Club cell protein 16 expression was higher in VV 22.5  than VV 0 . SP-D expression was higher in VV 30  than NV, while SP-C was higher in VV 30  and VV 22.5  than VV 0.  In conclusion, VV 22.5  improved respiratory system elastance and homogeneity of airspace enlargement, mitigated inflammation and epithelial cell damage, while avoiding impairment of right cardiac function in experimental elastase-induced emphysema.

Variability in Tidal Volume Affects Lung and Cardiovascular Function Differentially in a Rat Model of Experimental Emphysema