English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Fgf10  is necessary for the development of a number of organs that fail to develop or are reduced in size in the null mutant. Here we have knocked out  Fgf10  specifically in the neural crest driven by  Wnt1cre . The  Wnt1creFgf10fl/fl  mouse phenocopies many of the null mutant defects, including cleft palate, loss of salivary glands, and ocular glands, highlighting the neural crest origin of the  Fgf10  expressing mesenchyme surrounding these organs. In contrast tissues such as the limbs and lungs, where  Fgf10  is expressed by the surrounding mesoderm, were unaffected, as was the pituitary gland where  Fgf10  is expressed by the neuroepithelium. The circumvallate papilla of the tongue formed but was hypoplastic in the conditional and  Fgf10  null embryos, suggesting that other sources of FGF can compensate in development of this structure. The tracheal cartilage rings showed normal patterning in the conditional knockout, indicating that the source of  Fgf10  for this tissue is mesodermal, which was confirmed using  Wnt1cre-dtTom  to lineage trace the boundary of the neural crest in this region. The thyroid, thymus, and parathyroid glands surrounding the trachea were present but hypoplastic in the conditional mutant, indicating that a neighboring source of mesodermal  Fgf10  might be able to partially compensate for loss of neural crest derived  Fgf10 .

Multiple Cranial Organ Defects after Conditionally Knocking Out Fgf10 in the Neural Crest