English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Since the beginning of VDAC's history in 1976 artificial lipid bilayer studies of native (Schein et al., 1976; Benz et al., 1992; Colombini and Mannella, 2012) and recombinant (Bayrhuber et al., 2008; Hiller et al., 2008; Ujwal et al., 2008; Teijido et al., 2012) VDAC preparations are used to operationally define differing states of VDAC channel regulation. Up to near past just one fully open and a series of partially closed states have been stated. Since 1989, human type-1 VDAC was shown to reside in the plasmalemma of mammalian cells, a fully closed VDAC-1 state has been postulated, putatively achieved by interactions with proteineous modulators, low molecular weight agonists, or posttranslational protein modifications, as there are acetylation, phosphorylation, and nitrosylation (Thinnes and Reymann, 1997; Thinnes, 2013). Correspondingly, three differing VDAC states are discussed in recent structural studies on type-1 vertebrate VDAC using varying biophysical or in silico approaches (Bayrhuber et al., 2008; Hiller et al., 2008; Ujwal et al., 2008; Teijido et al., 2012). These are: (1) open = anion-selective = N-terminal stretch of AA 1-25 inside the barrel; (2) partially closed = cation-selective = N-terminal stretch of AA 1-25 inside the barrel but in differing position; (3) fully closed = collapsed = impermeable for ions or flickering = N-terminal stretch outside the β-barrel and accessible for antibodies.

frontiers in physiology

After all, plasmalemmal expression of type-1 VDAC can be understood. Phosphorylation, nitrosylation, and channel modulators work together in vertebrate cell volume regulation and either apoptotic pathway