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Brucea javanica  ( Ya-dan-zi  in Chinese) is a well-known Chinese herbal medicine, which is traditionally used in Chinese medicine for the treatment of intestinal inflammation, diarrhea, malaria, and cancer. The formulation of the oil ( Brucea javanica  oil) has been widely used to treat various types of cancer. It has also been found that  B. javanica  is rich in chemical constituents, including quassinoids, triterpenes, alkaloids and flavonoids. Pharmacological studies have revealed that chemical compounds derived from  B. javanica  exhibit multiple bioactivities, such as anti-cancer, anti-bacterial, anti-diabetic, and others. This review provides a comprehensive summary on the pharmacological properties of the main chemical constituents presented in  B. javanica  and their underlying molecular mechanisms. Moreover, the review will also provide scientific references for further research and development of  B. javanica  and its chemical constituents into novel pharmaceutical products for disease management .

Major Constituents From Brucea javanica and Their Pharmacological Actions