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Kinesin family member 2C ( KIF2C ) is known as an oncogenic gene to regulate tumor progression and metastasis. However, its pan-cancer analysis has not been reported. In this study, we comprehensively analyzed the characteristics of  KIF2C  in various cancers. We found that  KIF2C  was highly expressed and corresponded to a poor prognosis in various cancers. We also found a significant correlation between KIF2C and clinicopathological characteristics, particularly in cervical cancer, which is the most common gynecological malignancy and is the second leading cause of cancer-related deaths among women worldwide.  KIF2C  mutation is strongly associated with the survival rate of cervical cancer, and  KIF2C  expression was significantly upregulated in cervical cancer tissues and cervical cancer cells. Moreover,  KIF2C  promoted cervical cancer cells proliferation, invasion, and migration  in vitro  and as well increased tumor growth  in vivo .  KIF2C  knockdown promotes the activation of the p53 signaling pathway by regulating the expression of related proteins. The rescue assay with KIF2C and p53 double knockdown partially reversed the inhibitory influence of KIF2C silencing on cervical cancer processes. In summary, our study provided a relatively comprehensive description of  KIF2C  as an oncogenic gene and suggested  KIF2C  as a therapeutic target for cervical cancer.

Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer